Carreira, Aura

 

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Aura Carreira

B.Sc., Biology, 1998 - Universidad de Alcalá, Madrid, Spain

Ph.D., Molecular Biology, 2005  - Universidad Autonoma de Madrid (CBMSO), Madrid, Spain

Postdoctoral Fellow, 2006-2010 - University of California, Davis, CA

  Current address:

Research Scientist
Institut Curie
26 rue d'Ulm
75248 Paris cedex 05
France
Tel: +33 (0)1 69 86 30 82
FAX: +33 (0)1 69 86 94 29
aura.carreira@curie.fr

Carreira, A., Hilario, J., Amitani, I., Baskin, R.J., Shivji, M.K.K., Venkitaraman, A.R., and Kowalczykowski, S.C. (2009)
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.

Cell, 136,
1032-1043, (doi:10.1016/j.cell.2009.02.019). PMID: 19303847; PMCID: PMC2669112  [Abstract] [Full Text] [PDF] [Supplemental Data]
(see Cell, In this Issue: BRCA2 Focuses RAD51 for Repair  [PDF])
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Carreira, A. and Kowalczykowski, S.C. (2009).
BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.
Cell Cycle,
21, 11-13. PMID: 19838057; PMCID: PMC3050000. [Full Text]  [PDF]

Kemp, M.G., Mason, A.C., Carreira, A., Reardon, J.T., Haring, S.J., Borgstahl, G.E.O., Kowalczykowski, S.C., Sancar, A., and Wold, M.S. (2010).
An alternative form of replication protein A expressed in normal human tissues supports DNA repair.
J. Biol. Chem., 285,
4788-4797 (published online 7 December 2009, as doi:10.1074/jbc.M109.079418). PMID: 19996105; PMCID: PMC2836084
[Abstract] [Full Text] [PDF]

Jensen, R.B., Carreira, A., and Kowalczykowski, S.C. (2010)
Purified human BRCA2 stimulates RAD51-mediated recombination.
Nature,
467, 678-683 (published online: August 22, 2010, doi: 10.1038/nature09399). PMID: 20729832; PMCID: PMC2952063  [Abstract] [Full Text] [PDF] [Supplementary Information]

(see UC Davis interview: [Video-Flash] [Video-MPEG4])
(see Nature News & Views: DNA Repair: A protein giant in its entirety [PDF])
(see Nature News: Breast cancer protein is finally purified Latest News [PDF])
(see American Cancer Society News: New finding may unlock secrets of BRCA mutations [PDF])
(see Biocompare, Life Sciences Articles, News: Protein made by breast cancer gene purified [PDF])
(see Biomedical Beat - National Institute of General Medical Sciences: BRCA2 Breakthrough  News [PDF])
(see Bionity.com: Protein made by breast cancer gene purified [PDF])
(see BioTechniques: New gels shed light on cancer-related protein [PDF])
(see Congressionally Directed Medical Research Programs (CDMRP), Breast Cancer Research Highlights: Successful isolation of BRCA2 (breast cancer type 2 susceptibility protein) and elucidation of its mechanistic functions underlying breast cancer tumorigenesis [PDF])
(see Davis Enterprise: Scientists dig into breast cancer origins [PDF])
(see Deutsches Ärzteblatt:
Brustkrebs-Protein im Labor hergestellt [PDF])
(see e! Science News: Protein made by breast cancer gene purified [PDF])
(see ebiotrade: "Nature": successfully isolated and purified human lung cancer gene BRCA2 protein [PDF])
(see Eurekalert.org: Protein made by breast cancer gene purified [PDF])
(see GENNewsHighlights: Researchers succeed in purifying protein expressed by BRCA2 [PDF])
(see GenomeWeb: The elusive protein, found [PDF])
(see Guttenberg Municipal Hospital, HealthDay Daily Newsfeed: Inner workings of gene tied to breast, ovarian cancer revealed [PDF])
(see Higher Colleges of Technology, HCT Libraries: BRCA2, purified, reveals some of its secrets [PDF])
(see The Hindu: Protein made by breast cancer gene 'purified' [PDF])
(see Innovations Report: Protein made by breast cancer gene purified [PDF])
(see Journal of the National Cancer Institute: BRCA2, purified, reveals some of its secrets [PDF])
(see Justmeans: New finding may unlock secrets of BRCA mutations [PDF])
(see Lahey Hospital and Medical Center, HealthDay News: Inner workings of gene tied to breast, ovarian cancer revealed [PDF])
(see Mammary Cell News: Breast cancer protein is finally purified [PDF])
(see MedGuru: Pure form of tumor protein extracted successfully [PDF])
(see Medical News Today: Purification of protein made by breast cancer gene [PDF])
(see medwireNews: Purification of BRCA2 protein allows understanding of its role in DNA repair [PDF])
(see ModernMedicine: Researchers isolate BRCA2 protein for first time [PDF])
(see MSN Health and Fitness: Inner workings of
gene tied to breast, ovarian cancer revealed [PDF])
(see Natureasia.com: BRCA2 protein characterized [PDF])
(see News, Chauthi Duniya: Breast-cancer protein purified [PDF])
(see NewScientist Health: Fundamental breast and ovarian cancer protein isolated [PDF])
(see Pharmaceutical Online: Protein made by breast cancer gene purified [PDF])
(see Santa Maria Law: Breast cancer research [PDF])
(see Science Codex: Protein made by breast cancer gene purified [PDF])
(see ScienceDaily: Protein made by breast cancer gene purified [PDF])
(see Softpedia News: Breast cancer protein scrutinized [PDF])
(see Synthesis, Fall/Winter 2010: Protein made by breast cancer gene purified [PDF])
(see Synthesis, Spring/Summer 2011: Solving a genetic puzzle: Major findings open doors in DNA repair research [PDF])
(see USNews Health: Inner workings of gene tied to breast, ovarian cancer revealed [PDF])
(see UC Davis Health System News: Protein made by breast cancer gene purified [PDF])
(see UC Davis News & Information: Protein made by breast cancer gene purified [PDF] [printable])
(see WSFA 12 News Montgomery, AL: Inner workings of gene tied to breast, ovarian cancer revealed [PDF])
(see Yahoo! Movies India: Breast-cancer protein purified [PDF])

Carreira, A. and Kowalczykowski, S.C. (2011)
Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms.
Proc. Natl. Acad. Sci. U.S.A., 108
, 10448-10453 (published online June 13, 2011, doi: 10.1073/pnas.1106971108). PMID: 21670257; PMCID: PMC3127913 [Abstract] [Full Text] [PDF] [Supporting Information]

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Martinez, J.S., von Nicolai, C., Kim, T., Ehlén, A., Mazin, A.V., Kowalczykowski, S.C., and Carreira, A. (2016)
BRCA2 regulates DMC1-mediated recombination through the BRC repeats.
Proc. Natl. Acad. Sci. USA 113
, 3515-3520 (published online March 29, 2016 as doi: 10.1073/pnas.1601691113). PMID: 26976601; PMCID: PMC4822569. [Abstract] [Full Text] [PDF] [Supporting Information]