Carreira, A.,
Hilario, J.,
Amitani, I., Baskin, R.J., Shivji, M.K.K., Venkitaraman, A.R., and
Kowalczykowski,
S.C.
(2009)
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Cell, 136,
1032-1043,
(doi:10.1016/j.cell.2009.02.019). PMID: 19303847;
PMCID: PMC2669112
[Abstract]
[Full Text] [PDF]
[Supplemental Data]
(see Cell, In this Issue:
BRCA2 Focuses RAD51 for Repair
[PDF])
Carreira, A.
and
Kowalczykowski,
S.C.
(2009).
BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51.
Cell Cycle,
21,
11-13. PMID: 19838057; PMCID: PMC3050000. [Full Text] [PDF]
Kemp, M.G.,
Mason, A.C.,
Carreira, A., Reardon, J.T., Haring, S.J., Borgstahl, G.E.O.,
Kowalczykowski, S.C., Sancar, A., and Wold, M.S. (2010).
An alternative form of replication protein A expressed in normal human tissues supports DNA
repair.
J. Biol. Chem., 285, 4788-4797 (published online 7 December 2009, as
doi:10.1074/jbc.M109.079418). PMID: 19996105;
PMCID: PMC2836084
[Abstract]
[Full Text]
[PDF]
Jensen, R.B.,
Carreira, A., and
Kowalczykowski, S.C.
(2010)
Purified human BRCA2 stimulates RAD51-mediated recombination.
Nature, 467, 678-683 (published online: August 22,
2010, doi: 10.1038/nature09399). PMID: 20729832; PMCID: PMC2952063
[Abstract] [Full Text] [PDF]
[Supplementary
Information]
(see UC Davis interview:
[Video-Flash]
[Video-MPEG4])
(see Nature News & Views:
DNA
Repair: A protein giant in its entirety [PDF])
(see Nature News:
Breast
cancer protein is finally purified
Latest News
[PDF])
(see American Cancer Society News:
New finding may unlock secrets of BRCA mutations
[PDF])
(see Biocompare, Life Sciences Articles, News:
Protein made by breast cancer gene purified
[PDF])
(see Biomedical Beat - National Institute of General Medical Sciences:
BRCA2 Breakthrough
News
[PDF])
(see Bionity.com:
Protein made by breast cancer gene purified
[PDF])
(see BioTechniques:
New gels shed light on cancer-related protein
[PDF])
(see Congressionally Directed Medical Research Programs (CDMRP), Breast
Cancer Research Highlights:
Successful isolation of BRCA2 (breast cancer type 2 susceptibility protein) and
elucidation of its mechanistic functions underlying breast cancer tumorigenesis
[PDF])
(see Davis Enterprise: Scientists dig into breast cancer origins
[PDF])
(see Deutsches Ärzteblatt:
Brustkrebs-Protein im
Labor hergestellt
[PDF])
(see e! Science News:
Protein made by breast cancer gene purified
[PDF])
(see ebiotrade:
"Nature": successfully isolated and purified human lung cancer gene BRCA2
protein
[PDF])
(see Eurekalert.org:
Protein made by breast cancer gene purified
[PDF])
(see GENNewsHighlights:
Researchers succeed in purifying protein expressed by BRCA2
[PDF])
(see GenomeWeb:
The elusive
protein, found
[PDF])
(see Guttenberg Municipal Hospital, HealthDay Daily Newsfeed:
Inner workings of gene tied to breast, ovarian cancer revealed
[PDF])
(see Higher Colleges of Technology, HCT Libraries:
BRCA2, purified, reveals some of its secrets
[PDF])
(see The Hindu:
Protein made by breast cancer gene 'purified'
[PDF])
(see Innovations Report:
Protein made by breast cancer gene purified
[PDF])
(see Journal of the National Cancer Institute:
BRCA2,
purified, reveals some of its secrets
[PDF])
(see Justmeans:
New finding may unlock secrets of BRCA mutations
[PDF])
(see Lahey Hospital and Medical Center, HealthDay News:
Inner workings of gene tied to breast, ovarian cancer revealed
[PDF])
(see Mammary Cell News:
Breast cancer protein is finally purified
[PDF])
(see MedGuru:
Pure form of tumor protein extracted successfully
[PDF])
(see Medical News Today:
Purification of
protein made by breast cancer gene
[PDF])
(see medwireNews:
Purification of BRCA2 protein allows understanding of its role in DNA repair
[PDF])
(see ModernMedicine:
Researchers isolate BRCA2 protein for first time
[PDF])
(see MSN Health and Fitness: Inner workings of
gene tied to breast, ovarian cancer revealed
[PDF])
(see Natureasia.com:
BRCA2
protein characterized
[PDF])
(see News, Chauthi Duniya:
Breast-cancer protein purified
[PDF])
(see NewScientist Health:
Fundamental breast and ovarian cancer protein isolated
[PDF])
(see Pharmaceutical Online:
Protein made by breast cancer gene purified
[PDF])
(see Santa Maria Law:
Breast
cancer research
[PDF])
(see Science Codex:
Protein made by breast cancer gene purified
[PDF])
(see ScienceDaily:
Protein
made by breast cancer gene purified
[PDF])
(see Softpedia News:
Breast cancer protein scrutinized
[PDF])
(see Synthesis, Fall/Winter 2010:
Protein made by breast cancer gene purified
[PDF])
(see Synthesis, Spring/Summer 2011:
Solving a genetic puzzle: Major findings open doors in DNA repair research
[PDF])
(see USNews Health:
Inner workings of gene tied to breast, ovarian cancer revealed
[PDF])
(see UC Davis Health System News:
Protein made
by breast cancer gene purified
[PDF])
(see UC Davis News & Information:
Protein made
by breast cancer gene purified
[PDF]
[printable])
(see WSFA 12 News Montgomery, AL: Inner workings of gene tied to
breast, ovarian cancer revealed
[PDF])
(see Yahoo! Movies India:
Breast-cancer protein purified
[PDF])
Carreira, A. and
Kowalczykowski, S.C.
(2011)
Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament
function by distinct mechanisms.
Proc. Natl. Acad. Sci. U.S.A., 108, 10448-10453 (published online
June 13, 2011, doi: 10.1073/pnas.1106971108). PMID: 21670257; PMCID: PMC3127913
[Abstract] [Full Text]
[PDF]
[Supporting Information]
Martinez, J.S., von Nicolai, C., Kim,
T., Ehlén, A.,
Mazin, A.V.,
Kowalczykowski, S.C., and
Carreira, A. (2016)
BRCA2 regulates DMC1-mediated recombination through the BRC repeats.
Proc. Natl. Acad. Sci. USA 113, 3515-3520 (published online March 29,
2016 as doi: 10.1073/pnas.1601691113). PMID: 26976601; PMCID: PMC4822569.
[Abstract]
[Full Text]
[PDF]
[Supporting Information]