Cejka, Petr



Petr Cejka

B.S., 1998, Biology (Emphasis:  Molecular Biology), - Charles University, Prague

M.S., 2000, Molecular Biology "cum laude" - Charles University, Prague

Ph.D., 2004, Biochemistry - University of Zürich

Postdoctoral Fellow, 2004-2007 - University of Zürich

Postdoctoral Fellow, 2007-2010 - University of California, Davis, CA

Assistant Project Scientist, 2010-2011 - University of California, Davis, CA

  Current address:

University of Zurich
Institute of Molecular Cancer Research
Winterthurerstrasse 190
CH-8057 Zurich, Switzerland
Tel: +41 44 63 54786

Cejka, P., Vondrejs, V., and Storchova, Z. (2001).
Dissection of the functions of the Saccharomyces cerevisiae RAD6 postreplicative repair group in mutagenesis and UV sensitivity.
Genetics. 159
, 953-63. PMID: 11729144; PMCID: PMC1461873.

Cejka, P., Stojic, L., Mojas, N., Russell, A.M., Heinimann, K., Cannavo, E., di Pietro, M., Marra, G., and Jiricny, J. (2003).
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1.
EMBO J. 22
, 2245-54. PMID: 12727890; PMCID: PMC156088.

Cejka, P., Marra, G., Hemmerle, C., Cannavo, E., Storchova, Z., and Jiricny, J. (2003).
Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability.
Cancer Res. 63
, 8113-7. PMID: 14678962.

di Pietro, M., Marra, G., Cejka, P., Stojic, L., Menigatti, M., Cattaruzza, M.S., and Jiricny, J. (2003).
Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine.
Cancer Res. 63
, 8158-66. PMID: 14678970.

Cejka, P., Stojic, L., Marra, G., and Jiricny J. (2004).
Is mismatch repair really required for ionizing radiation-induced DNA damage signaling?
Nat. Genet. 36
, 432-3. PMID: 15118672.

Papouli, E., Cejka, P., and Jiricny, J. (2004).
Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells.
Cancer Res. 64
, 3391-4. PMID: 15150090.

Stojic, L., Mojas, N., Cejka, P., di Pietro, M., Ferrari, S., Marra, G., and Jiricny, J. (2004).
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
Genes Dev. 18
, 1331-44. PMID: 15175264; PMCID: PMC420358.

Stojic, L., Cejka, P., and Jiricny, J. (2005).
High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair.
Cell Cycle 4
, 473-7. PMID: 15684614.

Klasen, M., Spillmann, F.J., Marra, G., Cejka, P., and Wabl, M. (2005).
Somatic hypermutation and mismatch repair in non-B cells.
Eur. J. Immunol. 35
, 2222-9. PMID: 15940670.

Cannavo, E., Marra, G., Sabates-Bellver, J., Menigatti, M., Lipkin, S.M., Fischer, F., Cejka, P., and Jiricny, J. (2005).
Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
Cancer Res. 65
, 10759-66. PMID: 16322221.

Cejka, P., Mojas, N., Gillet, L., Schar, P., and Jiricny J. (2005).
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae.
Curr. Biol. 15
, 1395-400. PMID: 16085492.

Cejka, P. and Kowalczykowski, S.C. (2010).
The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds Holliday junctions.
J. Biol. Chem., 285,
8290-8301 (published online January 19, 2010, as doi:10.1074/jbc.M109.083196).  PMID: 20086270;
PMCID: PMC2832980  [Abstract] [Full Text] [PDF]

Cejka, P., Cannavo, E., Polaczek, P., Masuda-Sasa, T., Pokharel, S., Campbell, J.L., and Kowalczykowski, S.C. (2010)
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.
Nature, 467, 112-116 (doi: 10.1038/nature09355). PMID: 20811461; PMCID: PMC3089589  [Abstract] [Full Text] [PDF] [Supplementary Information]

(see Egghead blog about research at UC Davis: DNA repair machine on the bench [PDF])

Cejka, P., Plank, J.L., Bachrati, C.Z., Hickson, I.D., and Kowalczykowski, S.C. (2010)
Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.
Nature Struct. Mol. Biol.,
17, 1377-1382 (published online October 10, 2010; doi: 10.1038/nsmb.1919). PMID: 20935631; PMCID: PMC2988882  [Abstract] [Full Text] [PDF] [Supplementary Material]

(see California Aggie: DNA separates like a magician's rings [PDF])
(see CheckOrphan, Research News: DNA and the 'magic rings' trick [PDF])
(see Davis Enterprise: Study shows DNA acts like a 'magic rings' trick [PDF])

(see Healthcanal: DNA and the 'magic rings' trick [PDF])
(see PhysOrg.com news: DNA and the 'magic rings' trick [PDF])
(see UC Davis Comprehensive Cancer Center: DNA and the 'magic rings' trick [PDF])
(see UC Davis Health System: DNA and the 'magic rings' trick [PDF])
(see UC Davis News and Information: DNA and the 'magic rings' trick  [Printable] [PDF])
(see UC Newsroom: Genetic magic trick may hold clues to Bloom's syndrome [PDF])

Cejka, P., Plank, J.L., Dombrowski, C.C., and Kowalczykowski, S.C. (2012)
Decatenation of DNA by the S. cerevisiae Sgs1–Top3–Rmi1 and RPA complex: A mechanism for disentangling chromosomes.
Mol. Cell,
47, 886-896 (published online August 15, 2012). PMID: 22885009; PMCID: PMC3462259 [Abstract] [Full Text] [PDF] [Supplemental Information]

Access the recommendation on F1000Prime

Cannavo, E., Cejka, P., and Kowalczykowski, S.C. (2013)
Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection.
Proc. Natl. Acad. Sci. U.S.A., 109
(published online April 15, 2013 as doi: 10.1073/pnas.1305166110). PMID: 23589858, PMCID: PMC3645542. [Abstract] [Full Text] [PDF] [Supporting Information]

Paeschke, K., Bochman, M.L., Garcia, P.D.,  Cejka, P., Friedman, K.L., Kowalczykowski, S.C., and Zakian, V.A. (2013)
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
Nature, 497, 458-62. (published online May 8, 2013 as doi: 10.1038/nature12149).  PMID: 23657261; PMCID: PMC3680789. [Abstract] [Full Text] [PDF] [Supplementary Information]
(see Innovations Report: Stability for the genome [PDF])
(see Nature New & Views: DNA replication: Driving past four-stranded snags  [PDF])
(see NSF Science360 New Service  [Full Text] [PDF])
(see Universität Würzburg
: Stability for the genome [PDF])

Bocquet, N., Bizard, A.H., Abdulrahman, W., Larsen, N.B., Faty, M., Cavadini, S., Bunker, R.D., Kowalczykowski, S.C., Cejka, P., Hickson, I.D., and Thomä, N.H. (2014)
Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1.
Nat. Struct. Mol. Biol., 21,
261-268. (published online February 9, 2014 as doi: 10.1038/nsmb.2775). PMID: 24509834; PMCID: PMC4292918.
[Abstract] [Full Text] [PDF] [Supplementary Text and Figures 1-6]

Fasching, C.L., Cejka, P., Kowalczykowski, S.C., and Heyer, W.D. (2015)
Top3-rmi1 dissolve rad51-mediated d loops by a topoisomerase-based mechanism.
Mol. Cell. 57
, 595-606 (published online February 19, 2015 as doi:
10.1016/j.molcel.2015.01.022). PMID: 25699708; PMCID: PMC4338411. [Abstract] [Full Text] [PDF] [SupplementaI Information]