Hilario, Jovencio

 

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Jovencio Hilario

B.S., 1994, Biochemistry - University of Illinois at Chicago; Chicago, IL

M.S., 1995, Chemistry - University of Illinois at Chicago; Chicago, IL

Ph.D., 2004, Chemistry -University of Illinois at Chicago; Chicago, IL

Postdoctoral Fellow, 2004-2009 - University of California, Davis, CA

  Current address:

Senior Scientist
Bio-Rad Laboratories
4000 Alfred Nobel Drive
Hercules, CA 94547
(510) 724-7000

Riccelli, P.V., Hilario, J., Gallo, F.J., Young, A.P., and Benight, A.S.  (1998).
DNA and RNA oligomer sequences from the 3 noncoding region of the chicken glutamine synthetase gene form intramolecular hairpins.
Biochemistry, 35, 15364-15372.

Vallone, P. M., Paner, T. M., Hilario, J., Lane, M. J., Faldasz, B. D., and Benight, A. S. (1999).
Melting studies of short DNA hairpins: Influence of loop sequence and adjoining base pair identity on hairpin thermodynamic stability.
Biopolymers, 50, 425-442.

Hilario, J., Drapcho, D., Curbelo, R., and Keiderling, T. A. (2001).
Polarization modulation Fourier transform infrared spectroscopy with digital signal processing. Comparison of vibrational circular dichroism methods.
Applied Spectroscopy, 55, 1435-1447.

Hilario, J., Kubelka, J., Syud, F. A., Gellman, S. H., and Keiderling, T. A. (2002). 
Spectroscopic characterization of selected β-sheet hairpin models.
Biopolymers (Biospectroscopy), 67, 233-236.

Kuznetsov, S.V., Hilario, J., Keiderling, T.A., and Ansari, A. (2003).
Spectroscopic studies of structural changes in two β-sheet forming peptides show an ensemble of structures that unfold non-cooperatively.
Biochemistry, 42, 4321-4332.

Hilario, J., Kubelka, J., and Keiderling, T.A. (2003).
Optical spectroscopic investigations of model β-sheet hairpins in aqueous solution.
J. Am. Chem. Soc., 125, 7562-7574,

Keiderling, T.A., Kubelka, J., Hilario, J. (2006).
Vibrational circular dichroism of biopolymers: Summary of methods and applications.
In Vibrational spectroscopy of biologic and polymeric materials; Gregoriou, V. and Braiman, M., Ed.; CRC Taylor & Francis, Boca Raton, FL
.

Hilario, J., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2009)
Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules.

Proc. Natl. Acad. Sci. U.S.A., 106
, 361-368 (published online January 2, 2009, doi: 10.1073/pnas.0811965106.) PMID: 19122145; PMCID: PMC2613362
[Abstract] [Full Text] [PDF] [Supporting Information] [Movie 1] [Movie 2] [Movie 3]
(see About Medicine: Fluorescent microscopy captures the repair protein Rad51 as it assembles into a filament on DNA [PDF])
(see Biocompare News: Human DNA repair process recorded in action [PDF])
(see Biology News Net: Human DNA repair process recorded in action [PDF])
(see Biophotonics: Mending broken DNA [PDF])

(see e! Science News: Human DNA repair process recorded in action [PDF])
(see EurekAlert: Human DNA repair process recorded in action [PDF])
(see Insciences Organisation: Human DNA repair process recorded in action [PDF])

(see Machines Like Us, News: Human DNA repair process recorded in action [PDF])
(see MacNewsWorld: EurekAlert: Human DNA repair process recorded in action [PDF])
(see Medical News Today: Fluorescent microscopy captures the repair protein Rad51 as it assembles into a filament on DNA [PDF])
(see Newsguide.us: Human DNA repair process recorded in action [PDF])
(see Newsweek, National News: Human DNA repair process recorded in action (Video) [PDF])
(see Overwhelming Evidence: Human DNA repair process video - by chance? [PDF])
(see Phys.org/News: Human DNA repair process recorded in action (Video) [PDF])
(see ScienceBlog: Human DNA repair process recorded in action [PDF])
(see Science Codex: Human DNA repair process recorded in action [PDF])
(see Science Daily: Human DNA repair process recorded in action [PDF])
(see ScienceMode.com: Human DNA repair process recorded in action [PDF])
(see The Sensuous Curmudgeon: Human DNA repair process recorded [PDF])
(see UCDavis News and Information: Human DNA repair process recorded in action Caught in the act: Our DNA under repair  [Video] [Printable])
(see Uncommon Descent: Human DNA repair process video - by chance? [PDF])

Carreira, A., Hilario, J., Amitani, I., Baskin, R.J., Shivji, M.K.K., Venkitaraman, A.R., and Kowalczykowski, S.C. (2009)
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.

Cell, 136,
1032-1043, (doi:10.1016/j.cell.2009.02.019). PMID: 19303847; PMCID: PMC2669112  [Abstract] [Full Text] [PDF] [Supplemental Data]
(see Cell, In this Issue: BRCA2 Focuses RAD51 for Repair  [PDF])
Access the recommendation on F1000Prime

Hilario, J. and Kowalczykowski, S.C. (2010).
Visualizing protein-DNA interactions at the single-molecule level.

Curr. Opin. Chem. Biol.,
14, 15-22. PMID: 19945909; PMCID: PMC2819561 [Abstract] [Full Text] [PDF]