Nimonkar, Amitabh



Amitabh Nimonkar

B.S., 1996, (with Honors) Life Sciences and Biochemistry, St. Xavier's College, University of Mumbai, Mumbai, India

M.S., 1998 (with Honors) Life Sciences (Biological Macromolecules), University of Mumbai, Mumbai, India

Ph.D., 2003, Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL

Postdoctoral Researcher, 2004-2010, University of California, Davis, CA

Project Scientist, 2010-2012, University of California, Davis, CA

  Current address:

Cardiovascular and Metabolic Diseases
Investigator II - Lab Head
Novartis Institutes for BioMedical Research
100 Technology Square #5603
Cambridge, MA 02139
Tel: (617) 871-7091

Nimonkar, A., Amitani, I., Baskin, R.J., and Kowalczykowski, S.C. (2007)
Single-molecule imaging of Tid1/Rdh54, a Rad54 homolog that translocates on duplex DNA and can disrupt joint molecules.
J. Biol. Chem, 282
, 30776-30784
PMID: 17704061. [Abstract] [Full Text] [PDF] [Supplemental Data] [Movie 1] [Movie 2] [Movie 3] [Movie 4]

Nimonkar, A.V., ÷zsoy, A.Z., Genschel, J., Modrich, P., and Kowalczykowski, S.C. (2008)
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.

Proc. Natl. Acad. Sci. U.S.A., 105
, 16906-16911 (published online October 29, 2008, as doi: 10.1073/pnas.0809380105). PMID: 18971343; PMCID: PMC2579351 [Abstract] [Full Text] [PDF] [Supporting Information]

Nimonkar, A.V., Sica, R.A., and Kowalczykowski, S.C. (2009)
Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules.
Proc. Natl. Acad. Sci. U.S.A., 106, 3077-3082 (published online February 9, 2009, doi:10.1073/pnas.0813247106).  PMID: 19204284; PMCID: PMC2651264 [Abstract] [Full Text] [PDF] [Supporting Information]

Nimonkar, A.V. and Kowalczykowski, S.C. (2009).
Second-end DNA capture in double-strand break repair: How to catch a DNA by its tail.

Cell Cycle, 8
, 1816-1817. PMID: 19471119; PMCID: PMC3051008. [Full Text] [PDF]

Nimonkar, A.V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J.L., Wyman, C., Modrich, P., and Kowalczykowski, S.C. (2011)
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

Genes & Dev.,
25, 350-362. PMID: 21325134; PMCID: PMC3042158. [Abstract] [Full Text] [PDF] [Supplemental Material]
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Ciccia, A., Nimonkar, A.V., Hu, Y., Hajdu, I., Achar, Y.J., Izhar, L., Petit, S.A., Adamson, B., Yoon, J.C., Kowalczykowski, S.C., Livingston, D.M., Haracska, L., and Elledge, S.J. (2012)
Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress.
Mol. Cell. 47
, 396-409 (published online June 14, 2012). PMID: 22704558; PMCID: PMC3613862 [Abstract] [Full Text] [PDF] [Supplemental Information]
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Nimonkar, A.V., Dombrowski, C.C., Siino, J. S., Stasiak, A. Z., Stasiak, A. and Kowalczykowski, S.C. (2012)
Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.
J. Biol. Chem., 287,
28727-28737 (published online published 29 June 2012 as 10.1074/jbc.M112.373290). PMID: 22761450; PMCID: PMC3436576 [Abstract] [Full Text] [PDF] [Supplemental Material]