Morimatsu, Katsumi

 

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Education

B.S., 1990, Biology, Osaka University, Japan

M.S., 1992, Physiology, Osaka University, Japan

Ph.D., 1995, Physiology, Osaka University, Japan

Professional Experience

1994-1997, Research Associate. Research Institute for Microbial Diseases, Osaka University, Japan

1997-1999, Research worker. Institute Curie, France

1999-2000, Research worker. Chalmers University of Technology, Sweden

2000-2003, Post-doctoral fellow.  Section of Microbiology, University of California-Davis, USA

2003-2006, Research worker. Chalmers University of Technology, Sweden

2000-2003, Post-doctoral fellow. Section of Microbiology, University of California-Davis, USA

2006-Present, Project Scientist. Microbiology and Molecular Genetics, University of California-Davis, USA

   

Morimatsu, K. and Horii T. (1995).
Analysis of the DNA binding site of Escherichia coli RecA protein.
Adv Biophys. 31
:23-48.

Morimatsu, K. and Horii T. (1995).
The DNA-binding site of the RecA protein. Photochemical cross-linking of Tyr103 to single-stranded DNA.
Eur J Biochem. Mar 15;228
(3):772-8.

Morimatsu, K., Horii, T., and Takahashi, M. (1995).
Interaction of Tyr103 and Tyr264 of the RecA protein with DNA and nucleotide cofactors. Fluorescence study of engineered proteins.
Eur J Biochem. Mar 15;228
(3):779-85.

Morimatsu, K. and Horii, T. (1995).
DNA-binding surface of RecA protein photochemical cross-linking of the first DNA binding site on RecA filament.
Eur J Biochem. Dec 15;234
(3):695-705.

Morimatsu, K., Maraboeuf, F., Hagmar, P., Nordén, B., Horii, T., and Takahashi, M. (1996).
Roles of Tyr103 and Tyr264 in the regulation of RecA-DNA interactions by nucleotide cofactors.
Eur J Biochem. Aug 15;240
(1):91-97.

Morimatsu, K., Morikawa, T., Tanabe, K., Bzik, D.J., and Horii, T. (1997)
Sequence diversity in the amino-terminal 47 kDa fragment of the Plasmodium falciparum serine repeat antigen.
Mol Biochem Parasitol. Jun;86
(2):249-54.

Morimatsu, K., Funakoshi, T., Horii, T., and Takahashi, M. (2001).
Interaction of tyrosine 65 of RecA protein with the first and second DNA strands.
J Mol Biol. Feb 16;306
(2):189-99.

Morimatsu, K., Takahashi, M., and Nordén, B. (2002).
Arrangement of RecA protein in its active filament determined by polarized-light spectroscopy.
Proc Natl Acad Sci U S A. Sep 3;99
(18):11688-93.

Kim, H.K., Morimatsu, K., Nordén, B., Ardhammar, M., and Takahashi, M. (2002).
ADP stabilizes the human Rad51-single stranded DNA complex and promotes its DNA annealing activity.
Genes Cells. Nov;7
(11):1125-34.

Stohl, E.A., Brockman, J., Burkle, K.L., Morimatsu, K, Kowalczykowski, S.C., and Seifert, H.S. (2003).
Escherichia coli
RecX inhibits RecA recombinase and coprotease activities in vitro and in vivo.
J. Biol. Chem., 278
, 2278-2285 (published November 9, 2002 as 10.1074/jbc.M210496200). PMID: 12427742. [Abstract] [Full Text] [PDF]

Morimatsu, K. and Kowalczykowski, S.C.  (2003).
RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: A universal step of recombinational repair.
Mol. Cell,
11, 1337-1347. PMID: 12769856. 
[Abstract] [Full Text] [PDF]

Frykholm, K., Morimatsu, K., and Nordén, B. (2006).
Conserved conformation of RecA protein after executing the DNA strand-exchange reaction. A site-specific linear dichroism structure study.
Biochemistry. Sep 19;45(37):11172-8.

Morimatsu, K. and Takahashi, M. (2006).
Structural analysis of RecA protein-DNA complexes by fluorescence-detected linear dichroism: absence of structural change of filament for pairing of complementary DNA strands.
Anal. Biochem. Nov 15;358(2):192-8.

Takahashi, M., Maraboeuf, F., Morimatsu, K., Selmane, T., Fleury, F., and Nordén, B. (2007).
Calorimetric analysis of binding of two consecutive DNA strands to RecA protein illuminates mechanism for recognition of homology.
J. Mol. Biol. 365
, 603-611. PMID: 17097680.

Reymer, A., Frykholm, K., Morimatsu, K., Takahashi, M., and Nordén, B. (2009).
Structure of human Rad51 protein filament from molecular modeling and site-specific linear dichroism spectroscopy.
Proc. Natl. Acad. Sci. (USA) 106
, 13248-13253, doi: 10.1073/pnas.0902723106. PMID: 19587234; PMCID: PMC2726390.

Handa, N., Morimatsu, K., Lovett, S.T., and Kowalczykowski, S.C. (2009).
Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli.
Genes & Dev.,
23, 1234-1245. PMID: 19451222; PMCID: PMC2685532 
[Abstract]  [Full Text]  [PDF] [Supplemental Information]

Morimatsu, K., Wu, Y., and Kowalczykowski, S.C. (2012).
RecFOR proteins target RecA protein to a DNA gap with either DNA or RNA at the 5' terminus: Implication for repair of stalled replication forks.
J. Biol. Chem.
287, 35621-35630 (published online 17 August 2012 as 10.1074/jbc.M112.397034). PMID: 22902627; PMCID: PMC3471720 [Abstract] [Full Text] [PDF]