Lada, Artem



Artem Lada

B.S., 2005, Biological and Soil Sciences. Saint-Petersburg State University, Russia

M.S., 2007, Genetics and Breeding. Saint-Petersburg State University, Russia

Visiting Research Associate, 2008-2009, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA

PhD, 2014, Cancer Research. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA

Postdoctoral Researcher, 2014-2015, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA

Postdoctoral Researcher, 2015-present, University of California, Davis, USA


Tsaponina O.E., Lada A.G., Rubel A.A., Navolotskaya V.V., Petrova I.T., Inge-Vechtomov S.G., and Galkin A.P. (2005).
Analysis of Abeta-Sup35MC hybrid protein expression effects in yeast Saccharomyces cerevisiae. Ecologicheskaya genetika 3(1):22-33.

Lada A.G., Iyer L.M., Rogozin I.B., Aravind L., and Pavlov YI. (2007).
Incarnation of classical pro- and eukaryotic mechanisms of mutagenesis in hypermutagenesis and immunity of vertebrates.
Russian Journal of Genetics 43
(10):1093-1107. (Review). PMID: 18069336. [Abstract] [PDF]

Rubel A.A., Sayfitdinova A.F., Lada A.G., Nizhnikov A.A., Inge-Vechtomov S.G., and Galkin A.P. (2008).
Yeast chaperone Hsp104 controls gene expression at the posttranscriptional level. Molecular Biology (Moscow) 42(1):110-116. PMID: 18389629. [Abstract] [PDF]

Saifitdinova A.F., Nizhnikov A.A., Lada A.G., Rubel A.A., Magomedova Z.M., Ignatova V.V., Inge-Vechtomov S.G., and Galkin A.P. (2010).
[NSI (+)]: a novel non-Mendelian nonsense suppressor determinant in Saccharomyces cerevisiae. Current Genetics 56(5):467-78. PMID: 20668856. [Abstract] [Full Text] [PDF]

Lada A.G., Frahm-Krick C., Kozmin S.G., Mayorov V.I., Karpova T.S., Rogozin I.B., and Pavlov Y.I. (2011).
Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast. Biochemistry (Moscow) 76(1):131-146. PMID: 21568845; PMCID: PMC3906858. [Abstract] [Full Text] [PDF]

Lada A.G., Waisertreiger I.S., Grabow C.E., Prakash A., Borgstahl G.E., Rogozin I.B., and Pavlov Y.I. (2011). Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA.
PLoS One. 6
(9):e24848. doi:10.1371/journal.pone.0024848. PMID: 21935481; PMCID: PMC3174200. [Abstract] [Full Text] [PDF]

Baranovskiy A.G., Lada A.G., Siebler H.M., Zhang Y., Pavlov Y.I., and Tahirov T.H. (2012).
DNA polymerase delta and zeta switch by sharing accessory subunits of DNA polymerase delta.
Journal of Biological Chemistry. 287
(21):17281-17287. PMID: 22465957; PMCID: PMC3366816. [Abstract] [Full Text] [PDF] [Supplemental Information]

Lada A.G., Dhar A., Boissy R.J., Hirano M., Rubel A.A., Rogozin I.B., and Pavlov Y.I. (2012).
AID/APOBEC cytosine deaminase induces genome-wide kataegis.
Biology Direct. 7
:47. doi: 10.1186/1745-6150-7-47. PMID: 23249472; PMCID: PMC3542020. [Abstract] [Full Text] [PDF]

(see Biome: Rebellious enzymes: mutation showers in cancer induced by APOBEC 'kataegisters' [PDF])

Lada A.G., Stepchenkova E.I., Waisertreiger I.S., Noskov V.N., Dhar A., Eudy J.D., Boissy R.J., Hirano M., Rogozin I.B., and Pavlov Y.I. (2013).
Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.
PLoS Genet 9
(9): e1003736. doi:10.1371/journal.pgen.1003736. PMID: 24039593; PMCID: PMC3764175. [Abstract] [Full Text] [PDF]

Siebler H.M., Lada A.G., Baranovskiy A.G., Tahirov T.H., and Pavlov Y.I. (2014).
A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae.
DNA Repair (Amsterdam). PMID: 24819597; PMCID: PMC4225194. [Abstract] [Full Text] [PDF]

Lada A.G., Kliver S.F., Dhar A., Polev D.E., Masharsky A.E., Rogozin I.B., and Pavlov Y.I. (2015).
Disruption of transcriptional coactivator sub1 leads to genome-wide re-distribution of clustered mutations Induced by APOBEC in active yeast genes.
PLoS Genet 11
(5): e1005217. doi:10.1371/journal.pgen.1005217. PMID: 25941824; PMCID: PMC4420506. [Abstract] [Full Text] [PDF]

Rogozin I.B., Lada A.G., Goncearenco A., Green M.R., De S., Nudelman G., Panchenko A.R., Koonin E.V., and Pavlov Y. I. (2016).
Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.
Scientific Reports. 6
:38133. doi: 10.1038/srep38133. PMID: 27924834; PMCID: PMC5141443. [Abstract] [Full Text] [PDF]

Rogozin I.B., Pavlov Y.I., Goncearenco A., De S., Lada A.G., Poliakov E., Panchenko A.R., and Cooper D.N. (2017).
Mutational signatures and mutable motifs in cancer genomes.
Brief Bioinform
doi: 10.1093/bib/bbx049. PMID: 28498882. [Abstract] [Full Text] [PDF]

Lada A.G., Stepchenkova E.I., Zhuk A.S., Kliver S.F., Rogozin I.B., Polev D.E., and Pavlov Y.I. (2017).
Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.
Frontiers in Genetics 8
:202. doi: 10.3389/fgene.2017.00202. PMID: 29312434; PMCID: PMC5733079. [Abstract] [Full Text] [PDF]

Rogozin I.B., Goncearenco A., Lada A.G., De S., Nudelman G., Panchenko A.R., Cooper D.N., and Pavlov Y.I. (2018).
DNA polymerase η mutational signatures are found in a variety of different types of cancer.
Cell Cycle 17
(3):348-355.  doi: 10.1080/15384101.2017.1404208. PMID: 29139326; PMCID: PMC5914734. [Abstract] [Full Text] [PDF]

Rogozin I.B., Roche-Lima A., Lada A.G., Belinky F., Sidorenko I.A., Glazko G.V., Babenko V.N., Cooper D.N., and Pavlov Y.I. (2019).
Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes. Cancers (Basel).11(2), 211. doi:10.3390/cancers11020211. PMID: 30759888; PMCID: PMC6406962; DOI: 10.3390/cancers11020211. [Abstract] [Full Text] [PDF]