Exell, Jack




Jack Exell

M.S., 2008, Biological Chemistry - University of Sheffield, UK

Ph.D., 2015, Mechanism of hFEN1 inhibition - University of Sheffield, UK

Postdoctoral Scholar, 2015-present, University of California, Davis, CA


Patel, N., Atack J.M., Finger, L.D., Exell, J.C., Thompson, P., Tsutakawa, S.E., Tainer, J.A., Williams, D.M., and Grasby J.A. (2012).
Flap endonucleases pass 5' flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5' ends.
Nucleic Acids Res. 40
, 4507-4519. PMID: 22319208; PMCID: PMC3378889.

Finger, L.D., Patel, N., Beddows, A., Ma, L., Exell, J.C., Jardine, E., Jones, A,C., and Grasby J.A. (2013). Observation of unpaired substrate DNA in the flap endonuclease-1 active site.
Nucleic Acids Res. 41, 9839-9847. PMID: 23975198; PMCID: PMC3834815.

Patel, N., Exell, J.C., Jardine, E., Ombler, B., Finger, L.D., Ciani, B., and Grasby J.A. (2013).
Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.
J. of Biol. Chem. 288, 34239-34248. PMID: 24126913; PMCID: PMC3837164.

Pavankumar, T.L., Exell, J.C., and Kowalczykowski, S.C. (2016).
Direct fluorescent imaging of translocation and unwinding by individual DNA helicases.
Methods Enzymol. 581,
1-32. doi: 10.1016/bs.mie.2016.09.010. Epub 2016 Oct 18. PMID: 27793277; PMCID: PMC5854184.