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RecBCD enzyme is a bipolar DNA helicase.
Dillingham MS, Spies M, Kowalczykowski SC
Nature 2003 Jun 19 423(6942):893-7 [abstract on PubMed] [related articles] [order article]
Selected by | Phoebe Rice
Evaluated 11 Aug 2003
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Phoebe Rice
University of Chicago, United States

New Finding
Two different groups [1] have now conclusively shown that the RecBCD complex, which is important in the intial steps of DNA double-strand break repair in E. coli, contains two simultaneously active helicases. The two helicases load at a broken end, then proceed with opposite polarities, presumably one down each strand. This has interesting implications for how RecBCD produces the recombinogenic ssDNA tails that it then passes off to RecA, and for the mechanisms of certain other protein complexes involved in DNA repair. [1] See also Taylor & Smith, Nature 2003, 423:889 [PMID:12815437].

Evaluated 11 Aug 2003
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