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Escherichia coli RecO protein anneals ssDNA complexed with its cognate ssDNA-binding protein: A common step in genetic recombination.
Kantake N, Madiraju MV, Sugiyama T, Kowalczykowski SC
Proc Natl Acad Sci U S A 2002 Nov 26 99(24):15327-32 [abstract on PubMed] [related articles] [order article]
Selected by | Martin Marinus
Evaluated 7 Feb 2003
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Martin Marinus
University of Massachusetts Medical School, United States

New Finding
The results in this paper unite the roles of specific protein pairs in homologous genetic recombination: RecO-SSB in E coli; UvsY-gp32 in phage T4 and Rad52-RPA in budding yeast. The RecO or UvsY or Rad52 "mediator" proteins can anneal single-stranded complementary DNA strands bound by the cognate single-strand binding protein (SSB, gp32, and RPA respectively). The authors suggest that during repair of double-strand breaks the single-strand binding proteins (SSBPs) attach to single-stranded ends followed by the mediator proteins which help to displace the SSBPs and are replaced by the cognate strand exchange protein (RecA, UvsX and Rad51).

Evaluated 7 Feb 2003
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