Welcome Stephen Kowalczykowski homefeedbacksupportlog off  Last visit : 3-Nov-2004 

Recommended
F1000 Factor 3.0




add your evaluation
add dissenting opinions about this article

Escherichia coli RecO protein anneals ssDNA complexed with its cognate ssDNA-binding protein: A common step in genetic recombination.
Kantake N, Madiraju MV, Sugiyama T, Kowalczykowski SC
Proc Natl Acad Sci U S A 2002 Nov 26 99(24):15327-32 [abstract on PubMed] [related articles] [order article]
Selected by | Martin Marinus
Evaluated 7 Feb 2003
Relevant Sections

Faculty Comments
Faculty Member Comments
Martin Marinus
University of Massachusetts Medical School, United States
MICROBIOLOGY

Hypothesis
New Finding
The results in this paper unite the roles of specific protein pairs in homologous genetic recombination: RecO-SSB in E coli; UvsY-gp32 in phage T4 and Rad52-RPA in budding yeast. The RecO or UvsY or Rad52 "mediator" proteins can anneal single-stranded complementary DNA strands bound by the cognate single-strand binding protein (SSB, gp32, and RPA respectively). The authors suggest that during repair of double-strand breaks the single-strand binding proteins (SSBPs) attach to single-stranded ends followed by the mediator proteins which help to displace the SSBPs and are replaced by the cognate strand exchange protein (RecA, UvsX and Rad51).

Evaluated 7 Feb 2003
Faculty Comments

How to cite the Faculty of 1000 evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000: evaluations for Kantake N et al Proc Natl Acad Sci U S A 2002 Nov 26 99 (24) :15327-32 http://www.f1000biology.com/article/12438681/evaluation

2) To cite an evaluation by a specific Faculty member:

Martin Marinus: Faculty of 1000, 7 Feb 2003 http://www.f1000biology.com/article/12438681/evaluation


Submit your paper to BioMed Central
Published by
© 1999-2004 Biology Reports Ltd unless otherwise stated < info@facultyof1000.com >  Terms and conditions