PUBLICATIONS


Prasada Rao, H.B.D., Qiao, H., Bhatt, S.K., Bailey, L.R.J., Tran, H.D., Bourne, S.L., Qiu, W., Deshpande, A., Sharma, A.N., Beebout, C.J., Pezza, R.J. and Hunter, N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science DOI: 10.1126/science.aaf6407 Link

Hunter, N. (2015). Meiotic Recombination: The Essence of Heredity. Cold Spring Harb Perspect Biol. 2015 Oct 28. pii: a016618. doi: 10.1101/cshperspect.a016618
Pubmed

DNA Recombination. Cold Spring Harbor Perspectives in Biology. (2015). Edited by Stephen Kowalczykowski, Neil Hunter and Wolf-Dietrich Heyer. Cold Spring Harbor Press. Buy the book!

Tang, S., Wu, M.K.Y. Wu, Zhang, R. and Hunter, N. (2015). Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosis. Molecular Cell 57, 607-21. doi: 10.1016/j.molcel.2015.01.021 PubMed
Review

Qiao, H., Prasada Rao, H.B.D., Yang, Y., Fong, J.H., Cloutier, J.M., Deacon, D.C., Nagel, K.E., Swartz, R.K., Strong, E., Holloway, K., Schimenti, J., Ward, J. and Hunter, N. (2014). Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics doi:10.1038/ng.2858
PubMed

Copsey, A., Tang, S*. Jordan, P., Blitzblau, H., Newcombe, S., Lambacher, N. Chan, A.C., Newnham, L., Li, Z., Arumugam, P., Hochwagen, A., Neil Hunter, N., Hoffmann, E. (2013) Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genetics 9, e1004071, doi:10.1371/journal.pgen.1004071
PubMed
*Shangming Tang from the Hunter lab is joint first author.

Lao, J.P.*, Cloud, V., Grubb, J., Huang, C-C., Thacker, D., Lee, C-Y., Dresser, M.E., Hunter, N.† and Bishop† (2013). Meiotic crossover control by concerted action of Dmc1-Rad51 in homolog template bias and robust homeostatic regulation. PLoS Genetics 9, e1003978, doi: 10.1371/journal.pgen.1003978
*Jessica Lao from the Hunter lab is joint first author; †Hunter and Bishop are corresponding authors.
PubMed
Review

Sasanuma, H., Tawaramoto, M.S., Lao, J.P., Hosaka, H., Sanda, E., Suzuki, M., Yamashita, E., Hunter, N., Shinohara, A., A. Nakagawa, A., Shinohara, A. (2013). A new protein complex promoting the assembly of Rad51 filaments. Nature Communications doi: 10.1038/ncomms2678.
PubMed

Reynolds, A., Qiao, H., Yang, Y., Chen, J., Biswas, K., Holloway, K., Baudat, F., de Massy, B., Wang. J., Höög, C., Cohen, P. and Hunter, N. (2013). RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nature Genetics 45, 269-78.
PubMed
News & Views

Biswas, K., Das, R., Eggington, J.M., Qiao, H., North, S.L., Stauffer, S., Burkett, S., Betty K. Martin, B.S., Southon, E, Sizemore, S.C., Pruss, D., Bowles, K.R., Roa, B.B., Hunter, N., Tessarollo, L., Wenstrup, R.J., Byrd, R.A. and Sharan, S.K. (2012). Functional evaluation of BRCA2 variants mapping to the PALB2 binding and C-terminal DNA binding domains using a mouse ES cell–based assay. Human Molecular Genetics 21, 3993-4006.
PubMed

Qiao H., Chen, J., Reynolds, A., Höög, C., Paddy, M. and Hunter, N. (2012). Interplay between centromeres, synaptonemal complex and homologous recombination during mammalian meiosis. PLoS Genetics, PLoS Genet 8(6): e1002790. doi:10.1371/journal.pgen.1002790.
PubMed
Perspective

Lao, J.P., Tang, S. and Hunter, N. (2012). Native/Denaturing Two-Dimensional DNA Electrophoresis And Its Application To The Analysis Of Recombination Intermediates. In, Methods in Molecular Biology, DNA Electrophoresis: Methods and Protocols (Totowa, Humana Press).
PubMed

Zakheryevich, K, Tang, S., Ma, Y. and Hunter, N. (2012). Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell, 49 334-347.
PubMed
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Hunter, N. (2011). Double Duty For Exo1 During Meiotic Recombination. Cell Cycle 10(16), 2607-2609. PubMed

Hwang, Y-H. and Hunter, N. (2011). Mapping meiotic breaks: Spo11 oligonucleotides precisely mark the spots. Genome Biology 12, 111-114. doi:10.1186/gb-2011-12-4-111.
PubMed

Zakheryevich, K, Ma, Y., Tang, S., Hwang, Y-H., Boiteux, S. and Hunter, N. (2010). Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand-break resection and resolution of double-Holliday Junctions. Molecular Cell, 40, 1001-1015. PubMed
Highlighted by Faculty of 1000 Biology

Hunter, N. (2010). Meiosis. In, The Encyclopedia of Biological Chemistry 2
nd Edition, Lennarz, W. and Lane, M. (Eds), Elsevier Press, San Diego, In press.

Lao, J.P. and Hunter, N. (2010). Trying to Avoid Your Sister. PLoS Biology, 8(10): e1000519.
PubMed

Bzymek, M., Thayer, N.H., Oh, S.D., Kleckner, N. and Hunter, N. (2010). Double-Holliday Junctions are Intermediates of DNA Break Repair. Nature 464, 937-941.
PubMed
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Oh S.D., Jessop, L., Lao, J.P., Lichten, M.J. and Hunter, N.H. (2009). Stabilization and Electrophoretic Analysis of Meiotic Recombination Intermediates in Saccharomyces cerevisiae. In, Methods in Molecular Biology, Meiosis Methods and Protocols, Scott Keeney, ed. (Totowa, Human Press).
PubMed

Oh S.D., Lao, J.P. and Hunter, N. (2008). RecQ Helicase, Sgs1, and XPF-Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules During Meiotic Recombination. Molecular Cell 31, 324-336. PubMed

Hunter, N. (2008). Hop1 and the meiotic DNA-damage response. Cell 132, 731-732.
PubMed

Hunter, N. (2008). The RecQ DNA helicases: Jacks-of all-trades or master-tradesmen? Cell Research 18, 328-330. PubMed


Shinohara, M, Oh, S.D., Hunter, N. and Shinohara, A. (2008). Crossover assurance and crossover interference are distinctly regulated by the ZMM/SIC proteins during meiosis. Nature Genetics 40, 299-309.
PubMed
News & Views

Lao, J.P, Oh, S.D., Shinohara, M., Shinohara, A. and Hunter, N. (2008). Rad52 promotes post-invasion steps of meiotic double-strand-break repair. Molecular Cell 29, 517–524. PubMed
Highlighted by Faculty of 1000 Biology


Oh S.D., Lao, J.P., Hwang, P.Y-H., Taylor, A.F., Smith, G.R. and Hunter, N. (2007). BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing the formation of multi-chromatid joint molecules. Cell 130, 259-272.
PubMed
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Hunter, N. (2006). Meiotic Recombination. In, Topics in Current Genetics, Molecular Genetics of Recombination, Aguilera, A. and Rothstein, R. (Eds), Springer-Verlag, Heidelberg, pp. 381-442. Link

Cromie, G. A., Hyppa, R. W., Taylor, A. F., Zakharyevich, K., Hunter, N., and Smith, G. R. (2006). Single Holliday Junctions are intermediates of meiotic recombination. Cell 127, 1167-1178. PubMed
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Martini, E., Diaz, R.L., Hunter, N. and Keeney, S. (2006). Crossover homeostasis in yeast meiosis. Cell 126, 285-295.
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McDougall, A., Elliot, D.J. and Hunter, N. (2005). Pairing, connecting, exchanging, pausing and pulling chromosomes: Meeting on the cell-cycle regulation of meiosis. EMBO Reports, 6, 120-125.
PubMed

Hunter, N. (2004). Meiosis. In, The Encyclopedia of Biological Chemistry, 1
st Edition, Lennarz, W. and Lane, M. (Eds), Elsevier Press, San Diego, pp. 610-616. Link

Börner, V.G., Kleckner, N. and Hunter, N. (2004). Crossover/noncrossover differentiation, synaptonemal complex formation and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117, 29-45.
PubMed

Review Highlighted by Faculty of 1000 Biology

Hunter, N. (2003). Synaptonemal complexities and commonalities. Molecular Cell, 12, 533-535.
PubMed


de los Santos, T., Hunter, N., Lee, C., Larkin, B., Loidl, J., and Hollingsworth, N.M. (2003). The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast. Genetics, 164, 81-94.
PubMed Highlighted by Faculty of 1000 Biology

Blat, Y., Protacio, R., Hunter, N. and Kleckner, N. (2002). Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Cell, 111, 791-802.
PubMed

Hunter, N. and Kleckner, N. (2001). The single-end invasion: an asymmetric intermediate at the double-strand-break to double-Holliday junction transition of meiotic recombination. Cell, 106, 59-70.
PubMed

Hunter, N., Börner, G.V., Lichten, M. and Kleckner, N. (2001). gamma-H2AX illuminates meiosis. Nature Genetics, 27, 236-238.
PubMed

Wang, T.F., Kleckner, N. and Hunter, N. (1999). Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc Natl Acad Sci U S A, 96, 13914-13919. PubMed Comment

Hunter, N. and Borts, R.H. (1997). Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis. Genes Dev, 11, 1573-1582.
PubMed

Chambers, S.R., Hunter, N., Louis, E.J. and Borts, R.H. (1996). The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome loss. Mol Cell Biol, 16, 6110-6120. PubMed


Hunter, N., Chambers, S.R., Louis, E.J. and Borts, R.H. (1996). The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid. EMBO J, 15, 1726-1733. PubMed

Nemeth, A.H., Hunter, N., Coleman, M.P., Borts, R.H., Louis, E.J. and Davies, K.E. (1993). Rescue of a single yeast artificial chromosome from a cotransformation event utilizing segregation at meiosis. Genet Anal Tech Appl, 10, 123-127. PubMed