Publications › Privalsky


A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor.
Jimenez R, Privalsky ML.
Mol Cell Endocrinol. 2017 Feb 28. pii: S0303-7207(17)30157-0. doi:10.1016/j.mce.2017.02.044
PMID: 28257829

Corepressor diversification by alternative mRNA splicing is species specific.
Privalsky ML, Snyder CA, Goodson ML.
BMC Evol Biol. 2016 Oct 19;16(1):221
PMID: 27756201; PMCID: PMC5069798

Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.
Snyder CA, Goodson ML, Schroeder AC, Privalsky ML.
Mol Cell Endocrinol. 2015 Sep 15;413:228-35. doi: 10.1016/j.mce.2015.06.036. Epub 2015 Jul 10
PMID: 26166430

Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance.
Goodson ML, Young BM, Snyder CA, Schroeder AC, Privalsky ML.
Mol Cell Biol. 2014 Sep 2. doi: 10.1128/MCB.00554-14. [Epub ahead of print]
PMID: 25182530

Thyroid Hormones, T3 and T4, in the Brain.
Schroeder AC, Privalsky ML.
Front Endocrinol (Lausanne). 2014 Mar 31;5:40. eCollection 2014. Review
PMID: 24744751; PMCID: PMC3978256

The ability of thyroid hormone receptors (TRs) to sense T4 (3,5,3′,5′-tetraiodo-thyronine) as an agonist depends on receptor isoform and on cellular cofactors.
Schroeder A, Jimenez R, Young B, Privalsky ML.
Mol Endocrinol. 2014 Mar 27. [Epub ahead of print]
PMID: 24673558

The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins.
Hahm JB, Schroeder AC, Privalsky ML.
Mol Cell Endocrinol. 2013 Dec 8;383(1-2):80-95. doi10.1016/j.mce.2013.11.015

Research Resource: Identification of novel coregulators specific for thyroid hormone receptor-β2.
Hahm JB, Privalsky ML.
Mol Endocrinol. 2013 Apr 4. [Epub ahead of print]
PMID: 23558175

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM.
Journal of Clinical Investigation, 2012 Jul 2; 122(7):2428-38. doi:10.1172/JCI60580
PMID:22684107 PMCID:PMC3386813

SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β.
Mengeling BJ, Goodson ML, Bourguet W, Privalsky ML.
Molecular and Cellular Endocrinology, 2012 Apr 4; 351(2):306-16. doi:10.1016/j.mce.2012.01.006
PMID:22266197 PMCID:PMC3288673

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